Medical Supplies

Friedrich-Bergius-Ring 19
97076 Würzburg
Germany

Phone: (+49-931)3045580
Fax: (+49-931)3045590
http://www.virion-serion.com
dialog@virion-serion.de

Company Contacts
Department/ Name Address

Dr. Dieter Gernet / Sales Manager Export d.gernet@virion-serion.de

Olaf Degen / Leiter Produktmanagement o.degen@virion-serion.de

Company Figures
Number of employees 50-99
Year of foundation 1978
Area of business Laboratory Equipment

Diagnostics

Language: German Language: English Company Profile

Serion Immundiagnostica GmbH
Serion Immundiagnostica GmbH is one of the leading manufacturers of in vitro diagnostics with almost 30 years experience on the international market. Our product range includes high quality test systems for the detection of infectious and autoimmune diseases which we supply via a global network of distributors.

At MEDICA 2007 the new automat IMMUNOMAT™ TWIN SYSTEM as well as the applicable multiplex kits of the SERION Multianalyt™ range will be introduced. The technology of SERION Multianalyt™ allows the simultaneous quantification of several analytes in one sample preparation based on flow cytometry. SERION Multianalyt™ is a platform independent method for multiplex diagnostics. The new solution for automated test evaluation and its easy handling makes the test system a very economic solution meeting the increasing requirements in the range of diagnostics. These Multianalyt™ kits can be ordered for antibody diagnosis: Epstein-Barr-Viruses (IgG and IGM), Borrelia IgG and IgM, Pertussis IgA/IgM and Diphtheria-Tetanus-Bordetella pertussis Toxin- IgG.

Furthermore, our wide product range contains test systems for antibody (SERION ELISA classic) and antigen detection (SERION ELISA antigen). We are also highlighting our avidity tests for Toxoplasma and Rubella Virus as well as our tests validated for the use with cerebrospinal fluid samples.

Product Information
02.01 Analyser appliances

02.01.35 Microtiter plates

02.01.36 Fully automatic microtiter plate systems

03.02.03 Auto-immune diseases

03.02.03.03 Diagnostics / kits for the thyroid gland analyses

03.02.07 Immuno assay systems
Liquordiagnostik 23.08.2007

Die Liquordiagnostik ermöglicht den Nachweis und die Differenzierung von entzündlichen Prozessen im Zentralnervensystem (ZNS). Hierbei muss zwischen Krankheitsbildern unterschieden werden, deren Ursache die Infektion mit mikrobiellen Erregern darstellt oder chronisch entzündlichen Prozessen anderer Genese (z.B. Multiple Sklerose).

Bei vorhandenen neurologischen Symptomen und dem Verdacht auf eine Infektion des ZNS bzw. einen chronisch entzündlichen Prozesses basiert die erweiterte Liquordiagnostik auf der Erfassung von intrathekal gebildeten Antikörpern.

Im Liquor gefundene Antikörper können sowohl aus dem Plasma in den Liquorraum diffundiert sein als auch aus einer lokalen Synthese entstammen. Eine Aussage über intrathekal gebildete Antikörper ist nur durch die Bestimmung verschiedener Proteine im Serum und im Liquor, die Berechnung von Liquor-Serumquotienten für diese Proteine und die daraus abgeleitete Ermittlung des Antikörper-Index (AI) möglich.

Die aufwändige Berechnung des Antikörper-Index´ übernimmt das Excel-basierte Auswertungsprogramm SERION liquor, das auf Anfrage erhältlich ist.

Die Methode der SERION ELISA classic Liquordiagnostik sowie die Berechnung der erforderlichen Parameter richtet sich streng nach den Vorgaben von Prof. Dr. Hansotto Reiber et al.

Folgende SERION ELISA classic Nachweise wurden für die Liquordiagnostik evaluiert:

Masern Virus IgG, Röteln Virus IgG, Varicella-Zoster Virus IgG, Herpes Simplex Virus 1+2 IgG, Mumps Virus IgG, Cytomegalovirus IgG, FSME Virus IgG/IgM, Borrelia burgdorferi IgG/IgM.

Rheumatoid Factor Absorbent 23.08.2007

Rheumatoid factors are autoantibodies mainly of the IgM-class, which preferably bind to IgG immune-complexes. Therefore, false positive results may appear in the pathogen-specific IgM-detection. Furthermore, it is possible that weak-binding pathogen specific IgM antibodies are displaced by stronger-binding IgG antibodies. In this case, IgM-detection can bring about false negative results. For that reason, it is necessary to pre-treat samples for IgM detection with rheumatoid factor absorbent.

SERION Rf-Absorbent is used for the removal of IgM rheumatoid factors from serum, plasma samples or cerebrospinal fluid, prior to testing the sample for pathogen specific IgM antibodies in indirect immunoassays.

SERION Rf-Absorbent/Cag binds rheumatoid factors and antibodies that are directed towards host cells, at the same time. It has to be used for specific IgM antibody detection in addition to the following SERION ELISA classic tests:

Cytomegalovirus, Herpes Simplex Virus, Measles Virus, Parotitis Virus, Rubella Virus, Toxoplasma gondii, Varicella-Zoster Virus.

SERION-Rheumatoid Factor Absorbent

Order-No.
Z4 4 ml/20 tests
Z200 20 ml/100 tests

SERION-Rheumatoid factor Absorbent with control antigen
Order-No.
T4 4 ml/20 tests
T 200 20 ml/100 tests

SERION CFT reagents 23.08.2007

The Complement Fixation Test (CFT) is a classical serological method designed for parallel antibody detection of multiple parameters in infection serology.

All reagents for the classic Complement Fixation Test are standardized - therefore, pre-testing is not necessary.

Complement itself is an enzymatic component of blood which is activated - or „fixed“- by the presence of antigen-antibody complexes. Complement is only fixed by IgG1-, IgG2‑, IgG3- and IgM-antigen-complexes, whereby the last is particularly effective. In the activated form complement will attack and destroy membranes, however it is labile and will lose its activity in a short period of time. These properties are used in the CFT to demonstrate the presence of specific antibodies which may give information about e.g. a recent infection with a pathogen.

SERION ELISA antigen 23.08.2007

SERION ELISA antigen are enzyme immunoassays in a sandwich configuration for differential diagnostics of infections of the respiratory tract, based on direct antigen detection in patient’s samples (nasopharyngeal swabs, nasopharyngeal secretions, sputum, bronchial lavage fluid or material from cell culture).

Generally, pathogen identification is not feasible by clinical diagnosis of respiratory diseases therefore reliable laboratory methods are used for pathogen identification.

Antibody detection is not as suitable as direct pathogen detection for therapy or prophylaxis when performed at the onset of disease since at that stage antibody assays generally give negative results.

Direct pathogen detection, especially virus cell-culture, is very time consuming and cost intensive, diagnostic findings are only available after a few days or even weeks.

Direct antigen detection with immunoassays is an alternative for the detection of acute respiratory infections in comparison to the laboratory techniques described above.

SERION ELISA classic 23.08.2007

SERION ELISA classic products are standardized test systems for the qualitative and quantitative antibody detection of various pathogens causing infectious diseases.

The tests are suitable for qualitative and/or quantitative detection of human IgG, IgM or IgA antibodies. The high quality of our products is based on highly purified native or recombinant antigens. Single-point-quantification is economic and allows efficient testing also of small series. All tests are suitable for automated evaluation with the common commercially available equipment.

SERION ELISA classic Avidity Reagents 23.08.2007

Positive findings of IgM with the ELISA should not be interpreted as proof for primary infections (e.g. with Rubella or Toxoplasma) without further testing because IgM antibodies are also produced by polyclonal stimulation or in case of re-infections. There have also been cases with long-term persisting IgM antibodies. Under these circumstances avidity detection of IgG antibodies may determine which kind of infection it is. For avidity testing we offer in addition to the SERION ELISA classic Rubella Virus/ Toxoplasma IgG our SERION Rubella / Toxoplasma Avidity Reagents.

SERION MULTIANALYT™ System 23.08.2007

With this new system evaluation of several parameters in one single test is possible because encoded particles coated with antigen are used.

In contrary to the ELISA technique, which has a microtiter plate coated with only one antigen and therefore delivers only one piece of information in each test run, the particle-based test system provides information on the immune status with regards to a variety of possible diseases.

With this universal application and the uniform method it is possible to provide the individual amount of tests for each patient in a very cost effective and time efficient way.

SERION Reference Sera 23.08.2007

Reference sera are control reagents for internal quality control when using the SERION ELISA classic product line for antibody detection. These reagents are used in addition to controls supplied with the test kit, primarily for the determination of precision and reproducibility. They comply with individual laboratory conditions.

Values on the certificate are recommendations only, therefore each laboratory has to define its own values according to existing laboratory conditions

SERION neonatal 23.08.2007

Certain SERION ELISA classic tests are suitable not only for the standard use in laboratories but also for neonatal screening. They are evaluated for tests with dried blood spots (DBS) from newborns. This is a simple and gentle method for the detection of antibodies resp. infections in newborns.

The following SERION ELISA classic tests are evaluated for neonatal screening:

Cytomegalovirus IgM
Rubella Virus IgM
Toxoplasma gondii IgM

03.02.07.06 Enzyme immunoassay (EIA, ELISA, EMIT)

03.02.07.12 Immunoassay with particle count

03.02.07.17 Microparticles Polystyrene, dyed and magnetic

03.04.04 Mycology

03.04.05 Parasitology (Microbiology)

03.05.01 Bacteriology - Infectious immunology

03.05.03 Equipment and systems for HIV determination units

03.05.03.01 Diagnostic agents / kits for HIV determination

03.05.04 Controls / Standards / Calibrators - Infect. immunology

03.05.05 Equipment and systems for microbiological diagnosis/virology

03.05.06 Parasitology (Infectious immunology)